Upcoming Technological Advancements?

Surprises will always be surprises. But to improve your chances at guessing at those breakthroughs, learn about things science is studying now. Genetics is getting a lot of attention (not enough), so expect big breakthroughs there. Despite initial setbacks (destroying the careers of Pons and Fleischman), the phenomenon once called cold fusion is again being actively studied (see the references). If it can be made practical, it could have a huge impact.